The effect of taurine on dystrophic muscle tissue function
نویسنده
چکیده
....................................................................................................................... i CANDIDATE DECLARATION.......................................................................................... iii ACKNOWLEDGEMENTS................................................................................................ iv LIST OF PUBLICATIONS AND AWARDS....................................................................... vi TABLE OF CONTENTS.................................................................................................. vii LIST OF FIGURES.......................................................................................................... xv LIST OF TABLES......................................................................................................... xviii ABBREVIATIONS.......................................................................................................... xix CHAPTER ONE: PERSPECTIVES 1.1 Thesis scope ............................................................................................................. 1 CHAPTER TWO: REVIEW OF THE LITERATURE 2.1 Duchenne Muscular Dystrophy .................................................................................. 4 2.1.1 Dystrophin structure and function ...................................................................................... 4 2.1.2 Mechanical damage and membrane weakness ................................................................. 6 2.1.3 Ion channel dysfunction ..................................................................................................... 8 2.1.4 Impaired Ca2+ handling ................................................................................................... 11 2.1.5 Oxidative stress ................................................................................................................ 12 2.1.6 Chronic inflammation ....................................................................................................... 14 2.1.7 Impaired metabolism ........................................................................................................ 16 2.1.8 Muscle function impairments ............................................................................................ 17 i) E-C coupling ...................................................................................................................... 17 ii) Whole muscle function ...................................................................................................... 18 2.2 Mammalian models of dystrophy ............................................................................. 21 2.2.1 Canine muscular dystrophy .............................................................................................. 21 2.2.2 Mouse muscular dystrophy .............................................................................................. 22
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The effect of eight weeks of taurine supplementation on the amount of myostatin, fasting glucose, and insulin resistance in soleus muscle tissue in male rats with type 2 diabetes
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